There are 3 main forms of topical treatment
that are used for rosacea.
In Rosacea it reduces the inflammatory
papules and pustules and has little or no effect on the flushing
or vascular component of the disease. It has been shown to
reduce the papules and pustules by about 65% over a nine-week
course. The Metrogel formulation may have increased penetration
into the skin but may also cause some stinging. Topical treatment
is one way of avoiding oral antibiotics but in very inflammed
cases oral treatment may be required initially.
• Metrogel 0.75%
• Metrocream 0.75%
• Metrolotion 0.75%
• Noritate 1%
• Rosasol 1% plus sunscreen
Sodium Sulfacetamide is a sulfonamide
antibiotic that competes with para-aminbenzoic acid. Sulfur
has a keratolytic action, and is believed to an anti-inflammatory
It is of benefit in reducing pigment
formation in the skin by its anti-tyrosinase action in hyperactive
melanocytes. It therefore is useful in the treatment of melasma.
The activity against Proprionibacteria acnes and Staphyloccocus
epidermidis makes it active in the treatment of acne and rosacea.
It appears to inhibit bacterial protein synthesis. It has
mild anti-comodone action. The anti-inflammatory properties
are a result of its oxy radical scavenging action.
• Azelex® 20% cream 30,
50 gms (Allergan)
• Skinoren® (Shering AG)
• Finnevin® (Berlex)